Atrial fibrillation and microRNAs

Front Physiol. 2014 Jan 24:5:15. doi: 10.3389/fphys.2014.00015. eCollection 2014.


Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

Keywords: apoptosis; atrial fibrillation; electrical remodeling; electrophysiology; fibrosis; microRNA (miRNA); structural remodeling.

Publication types

  • Review