Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials

Lancet Oncol. 2014 Feb;15(2):e78-89. doi: 10.1016/S1470-2045(13)70493-5.


Small-cell lung cancer represents about 15% of all lung cancers; increasingly, randomised controlled trials of this disease measure the health-related quality of life of patients. In this Systematic Review we assess the adequacy of reporting of health-related quality-of-life methods in randomised controlled trials of small-cell lung cancer, and the potential effect of this reporting on clinical decision making. Although overall reporting of health-related quality of life was acceptable, improvements are needed to optimise the use of health-related quality of life in randomised controlled trials.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Activities of Daily Living
  • Adaptation, Psychological
  • Cost of Illness
  • Evidence-Based Medicine
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / psychology*
  • Lung Neoplasms / therapy
  • Prognosis
  • Quality of Life*
  • Randomized Controlled Trials as Topic / methods*
  • Research Design*
  • Small Cell Lung Carcinoma / diagnosis
  • Small Cell Lung Carcinoma / psychology*
  • Small Cell Lung Carcinoma / therapy
  • Surveys and Questionnaires