A management algorithm based on delayed bleeding after wide-field endoscopic mucosal resection of large colonic lesions

Nicholas G Burgess; Stephen J Williams; Luke F Hourigan; Gregor J Brown; Simon A Zanati; Rajvinder Singh; William Tam; Joshua Butt; Karen Byth; Michael J Bourke

doi:10.1016/j.cgh.2014.01.026

A management algorithm based on delayed bleeding after wide-field endoscopic mucosal resection of large colonic lesions

Clin Gastroenterol Hepatol. 2014 Sep;12(9):1525-33. doi: 10.1016/j.cgh.2014.01.026. Epub 2014 Jan 28.

Authors

Affiliations

¹ Departments of Gastroenterology and Hepatology, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia.
² Departments of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Departments of Gastroenterology and Hepatology, Greenslopes Private Hospital, Brisbane, Queensland, Australia.
³ Departments of Gastroenterology and Hepatology, The Alfred Hospital, Melbourne, Victoria, Australia; Departments of Gastroenterology and Hepatology, Epworth Hospital, Melbourne, Victoria, Australia.
⁴ Departments of Gastroenterology and Hepatology, The Alfred Hospital, Melbourne, Victoria, Australia; Departments of Gastroenterology and Hepatology, Western Hospital, Melbourne, Victoria, Australia.
⁵ Departments of Gastroenterology and Hepatology, Lyell McEwin Hospital, Adelaide South Australia, Australia.
⁶ Departments of Gastroenterology and Hepatology, The Alfred Hospital, Melbourne, Victoria, Australia.
⁷ National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney, New South Wales, Australia.
⁸ Departments of Gastroenterology and Hepatology, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia. Electronic address: michael@citywestgastro.com.au.

PMID: 24480678
DOI: 10.1016/j.cgh.2014.01.026

Abstract

Background & aims: Bleeding is the main complication of wide-field endoscopic mucosal resection (WF-EMR) for large colonic lesions. Few studies have examined bleeding outcomes after WF-EMR, and there are no evidence-based guidelines for management of bleeding in this group. We analyzed outcomes of patients with clinically significant post-EMR bleeding (CSPEB) and present a management algorithm based on our findings.

Methods: In a prospective study, we collected data from WF-EMR of sessile colorectal polyps 20 mm or larger from 1039 patients who participated in the Australian Colonic Endoscopic resection multicenter study from July 2008 through May 2012. Data included patient and lesion characteristics and procedural, clinical, and histologic outcomes. Patients participated in a structured telephone interview 14 days after the procedure; independent predictors of a moderate or severe outcome by American Society of Gastrointestinal Endoscopists criteria, or any intervention for hemostasis, were identified.

Results: Sixty-two patients had CSPEB (6.0%); 34 were managed conservatively (55%) and 27 underwent colonoscopy (44%). One patient had primary embolization. Endoscopic therapy was applied in 21 cases; 14 had active bleeding. Two of the conservatively managed cases underwent colonoscopy for rebleeding after discharge. On multivariable analysis, moderate or severe bleeding events were associated with hemodynamic instability (odds ratio, 12.3; P = .046) and low level of hemoglobin at presentation (odds ratio, 0.50 per 1.0 g/dL; P = .005). Intervention for hemostasis was associated with hourly or more frequent hematochezia (odds ratio, 36.7; P = .001), American Society of Anesthesiologists grade 2 or higher (odds ratio, 20.1; P < .001), and transfusion (odds ratio, 18.7; P = .003).

Conclusions: Based on a multicenter prospective study, CSPEB resolves spontaneously in 55% of patients. We developed a risk factor-based algorithm that might assist physicians in the management of bleeding. Patients responding to initial resuscitation can be observed, with a lower threshold for intervention in those with the identified risk factors.

Keywords: ACE Resection Study; Colonic Polyps; Colorectal Neoplasms; Hemorrhage; Polypectomy.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Algorithms
Australia
Colonic Diseases / surgery*
Endoscopy / adverse effects*
Female
Gastrointestinal Hemorrhage / diagnosis*
Gastrointestinal Hemorrhage / therapy*
Humans
Interviews as Topic
Male
Middle Aged
Postoperative Complications / diagnosis*
Postoperative Complications / therapy*
Prospective Studies