Gestodene: a review of its pharmacology, potency and tolerability in combined contraceptive preparations

Contraception. 2014 Apr;89(4):242-52. doi: 10.1016/j.contraception.2013.12.003. Epub 2013 Dec 19.


Combined progestin-estrogen pills are an established and reliable contraceptive option used by women worldwide. Combined oral contraceptives (COCs) containing the progestins--gestodene, desogestrel or norgestimate--were developed to minimize androgenic side effects and are considered an effective, well-tolerated contraceptive option. Gestodene achieves contraceptive efficacy with the lowest dose of any progestin in a COC, and has an established and favorable short- and long-term tolerability profile. In this review we present an overview of the pharmacology, potency and tolerability of gestodene.

Keywords: Combined oral contraceptives; Ethinyl estradiol; Gestodene; Pharmacology; Review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Contraceptives, Oral, Combined
  • Drug Interactions
  • Female
  • Humans
  • Menstrual Cycle / drug effects
  • Norpregnenes / adverse effects
  • Norpregnenes / pharmacology*
  • Progestins / adverse effects
  • Progestins / pharmacology*


  • Contraceptives, Oral, Combined
  • Norpregnenes
  • Progestins
  • Gestodene