Golgi feels DNA's pain

Cell. 2014 Jan 30;156(3):392-3. doi: 10.1016/j.cell.2014.01.030.

Abstract

The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular transport through DNA-PK-mediated GOLPH3 phosphorylation, thereby linking the DNA damage response to Golgi regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • DNA Damage*
  • DNA-Activated Protein Kinase / metabolism*
  • Golgi Apparatus / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Myosins / metabolism*

Substances

  • GOLPH3 protein, human
  • MYO18A protein, human
  • Membrane Proteins
  • DNA-Activated Protein Kinase
  • Myosins