Abstract
Hantaviruses are causative agents of two rodent-borne zoonoses, hemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE) in the Old World and hantavirus pulmonary syndrome (HPS) in the New World. Serological examinations to detect hantavirus antibodies have been most widely used for surveillance among humans and rodent reservoirs. Here, we will review antigenic structure of nucleocapsid (N) protein of hantaviruses and application of recombinant N protein as diagnostic antigen for screening and serotyping.
Keywords:
Alternative neutralization test; Immunochoromatography.
Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Viral / blood*
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Antigens, Viral / blood*
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Capsid Proteins / chemistry*
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Capsid Proteins / genetics
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Capsid Proteins / immunology
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Chromatography, Affinity
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Gene Expression
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Hantavirus Infections / blood
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Hantavirus Infections / diagnosis*
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Hantavirus Infections / immunology
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Hantavirus Infections / virology
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Humans
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Neutralization Tests
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Orthohantavirus / classification
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Orthohantavirus / genetics
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Orthohantavirus / immunology*
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Phylogeny
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
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Viral Core Proteins / chemistry*
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Viral Core Proteins / genetics
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Viral Core Proteins / immunology
Substances
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Antibodies, Viral
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Antigens, Viral
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Capsid Proteins
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Recombinant Proteins
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Viral Core Proteins
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nucleocapsid protein, Hantaan virus