Quercetin and omega 3 ameliorate oxidative stress induced by aluminium chloride in the brain

J Mol Neurosci. 2014 Aug;53(4):654-60. doi: 10.1007/s12031-014-0232-8. Epub 2014 Feb 1.

Abstract

Exposure to high levels of aluminum (Al) leads to neurodegeneration, which may be mediated through over-generation of free radicals. So, in the present study, we investigated the ability of both quercetin and omega 3 to ameliorate adverse effects of Al on brain antioxidants by monitoring the main brain antioxidant enzymes on molecular and cellular levels. The obtained results indicated that Al induced oxidative stress through induction of free radical production and inhibition of activity and expression of the antioxidant enzymes catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx); and at the same time induced superoxide dismutase (SOD) activity and gene expression. Both quercetin (QE) and omega 3 have the ability to overcome Al-induced oxidative stress, manifested by the significant reduction in free radical concentration and induction of the activity and gene expression of the brain antioxidant enzymes.

MeSH terms

  • Aluminum Chloride
  • Aluminum Compounds / toxicity
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Brain / drug effects*
  • Brain / metabolism
  • Catalase / genetics
  • Catalase / metabolism
  • Chlorides / toxicity
  • Dietary Supplements
  • Fatty Acids, Omega-3 / administration & dosage
  • Fatty Acids, Omega-3 / pharmacology*
  • Glutathione Peroxidase / genetics
  • Glutathione Peroxidase / metabolism
  • Glutathione Reductase / genetics
  • Glutathione Reductase / metabolism
  • Male
  • Oxidative Stress*
  • Quercetin / administration & dosage
  • Quercetin / pharmacology*
  • Rats
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism

Substances

  • Aluminum Compounds
  • Antioxidants
  • Chlorides
  • Fatty Acids, Omega-3
  • Aluminum Chloride
  • Quercetin
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Reductase