Facing the truth about nanotechnology in drug delivery

ACS Nano. 2013 Sep 24;7(9):7442-7. doi: 10.1021/nn404501g.


Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disclosure / trends*
  • Drug Delivery Systems / adverse effects*
  • Drug Delivery Systems / trends*
  • Forecasting
  • Humans
  • Nanocapsules / adverse effects*
  • Nanocapsules / therapeutic use*
  • Nanotechnology / trends*
  • Translational Medical Research / trends*


  • Nanocapsules