The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus

Int J Food Sci Nutr. 2014 Jun;65(4):515-20. doi: 10.3109/09637486.2014.880671. Epub 2014 Feb 4.

Abstract

Objective: To assess the effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.

Methods: In a double-blinded, placebo-controlled clinical trial, 70 type 2 diabetic patients were enrolled. They allocated randomly into ginger group and control group. They consumed 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks. Serum sugar, lipids, CRP, PGE2 and TNFα were measured before and after intervention.

Results: Ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with placebo group (p < 0.05). There were no significant differences in HDL, LDL and TNFα between two groups (p > 0.05).

Conclusion: Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered as an effective treatment for prevention of diabetes complications.

Keywords: Blood sugar; ginger; inflammation; insulin sensitivity; serum lipids; type 2 diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Hyperglycemia / prevention & control*
  • Hyperlipidemias / complications
  • Hyperlipidemias / prevention & control
  • Hypoglycemic Agents / therapeutic use*
  • Hypolipidemic Agents / therapeutic use*
  • Inflammation Mediators / blood
  • Insulin Resistance
  • Iran
  • Lipids / blood
  • Male
  • Middle Aged
  • Rhizome
  • Zingiber officinale*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Inflammation Mediators
  • Lipids

Associated data

  • IRCT/201204159472N1