Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses

Curr Opin Virol. 2014 Apr;5:16-23. doi: 10.1016/j.coviro.2014.01.004. Epub 2014 Feb 1.

Abstract

A quartet of attachment proteins and a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses. While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4. SLAM binds near the stalk-head junction of the hemagglutinin. Nectin-4 binds a hydrophobic groove located between blades 4 and 5 of the hemagglutinin β-propeller head. The mutated vaccine strain hemagglutinin binds in addition the ubiquitous protein CD46, which explains attenuation. The measles virus entry concert has four movements. Andante misterioso: the virus takes over the immune system. Allegro con brio: it rapidly spreads in the upper airway's epithelia. 'Targeting' fugue: the versatile orchestra takes off. Presto furioso: the virus exits the host with thunder. Be careful: music is contagious.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / genetics
  • Antigens, CD / metabolism
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / metabolism
  • Hemagglutinins, Viral / chemistry*
  • Hemagglutinins, Viral / genetics
  • Hemagglutinins, Viral / metabolism*
  • Humans
  • Measles / genetics
  • Measles / metabolism*
  • Measles / virology
  • Measles virus / chemistry
  • Measles virus / genetics
  • Measles virus / metabolism*
  • Protein Binding
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Virus / chemistry
  • Receptors, Virus / genetics
  • Receptors, Virus / metabolism*
  • Signaling Lymphocytic Activation Molecule Family Member 1

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • Hemagglutinins, Viral
  • LNIR protein, human
  • Receptors, Cell Surface
  • Receptors, Virus
  • Signaling Lymphocytic Activation Molecule Family Member 1