Neuropathic pain in neuromyelitis optica affects activities of daily living and quality of life

Mult Scler. 2014 Oct;20(12):1658-61. doi: 10.1177/1352458514522103. Epub 2014 Feb 3.


Though pain in neuromyelitis optica (NMO) has been described in two recent reports, the proportion with true neuropathic pain (NP), its features, impact on activities of daily living (ADL) and quality of life has not been well characterised. A cross-sectional study of 50 NMO patients with transverse myelitis was performed using Douleur Neuropathique 4, Brief Pain Inventory, Extended Disability Status Scale and Short Form 36. NP was identified in 62% of patients. Pain was constant in 68% affecting most ADL. Pain was associated with significant reduction of the SF36 Mental Composite Score. The high prevalence of NP and associated disability necessitates an in-depth enquiry in patients with NMO.

Keywords: Neuromyelitis optica; SF36; aquaporin 4; brief pain inventory; demyelinating; neuropathic pain; pain; quality of life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / immunology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myelitis, Transverse / complications
  • Neuralgia / etiology
  • Neuralgia / immunology
  • Neuralgia / physiopathology*
  • Neuromyelitis Optica / complications
  • Neuromyelitis Optica / immunology
  • Neuromyelitis Optica / physiopathology*
  • Quality of Life*
  • Young Adult


  • Autoantibodies