Meta-analysis of loci associated with age at natural menopause in African-American women

Hum Mol Genet. 2014 Jun 15;23(12):3327-42. doi: 10.1093/hmg/ddu041. Epub 2014 Feb 2.

Abstract

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • African Americans / genetics*
  • Age Factors
  • Chromosomes, Human
  • European Continental Ancestry Group / genetics*
  • Female
  • Genetic Loci
  • Genetic Variation
  • Genome-Wide Association Study
  • Humans
  • Menopause / ethnology*
  • Menopause / genetics*
  • United States

Grant support