Standing waves as an explanation for generic stationary correlation patterns in noninvasive EEG of focal onset seizures

Brain Connect. 2014 Mar;4(2):131-44. doi: 10.1089/brain.2013.0192.

Abstract

Cerebral electrical activity is highly nonstationary because the brain reacts to ever changing external stimuli and continuously monitors internal control circuits. However, a large amount of energy is spent to maintain remarkably stationary activity patterns and functional inter-relations between different brain regions. Here we examine linear EEG correlations in the peri-ictal transition of focal onset seizures, which are typically understood to be manifestations of dramatically changing inter-relations. Contrary to expectations we find stable correlation patterns with a high similarity across different patients and different frequency bands. This skeleton of spatial correlations may be interpreted as a signature of standing waves of electrical brain activity constituting a dynamical ground state. Such a state could promote the formation of spatiotemporal neuronal assemblies and may be important for the integration of information stemming from different local circuits of the functional brain network.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / physiopathology*
  • Brain Waves*
  • Data Interpretation, Statistical
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Net / physiopathology*
  • Seizures / physiopathology*
  • Young Adult