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Case Reports
. 2013 Oct;19(4):487-90.
doi: 10.4103/0971-6866.124383.

Dyschromatosis universalis hereditaria: Infrequent genodermatoses in India

Hari Kishan Kumar Yadalla  1 , Srivalli Pinninti  1 , Anagha Ramesh Babu  1
Affiliations
Case Reports

Dyschromatosis universalis hereditaria: Infrequent genodermatoses in India

Hari Kishan Kumar Yadalla et al. Indian J Hum Genet. 2013 Oct.

Abstract

Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis reported initially and mainly in Japan. However, subsequent cases have been reported from other countries. We report a case of DUH in a south Indian woman with a positive family history with cosmetic disfigurement and severe psychological impairment.

Keywords: Dyschromatosis symmetrica hereditaria; dyschromatosis universalis hereditaria; genodermatosis; psychological impairment.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Generalized, 0.5 - 1 cm hyperpigmented macules interspersed with spotty hypopigmented macules. The lesions were dense on the limbs and trunk with sparing of the palms and soles
Figure 2
Figure 2
Multiple dense hyper - and hypopigmented lesions over arms
Figure 3
Figure 3
Histopathology of the skin lesion shows epidermis was mildly atrophic with hyperkeratosis. Basal layers showed mild vacuolar change, papillary dermis with melanin incontinence, and dilated dermal vessels (hematoxylin and eosin (H and E, ×10)
Figure 4
Figure 4
Histopathology of the skin lesion: In high power, section shows increase in pigment extending into the stratum spinosum. Dermis showed mild perivascular and periadnexeal lymphomononuclear infitrate (H and E, × 10)
See this image and copyright information in PMC

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