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, 9 (1), e87396

Increased Diagnostic Yield of Capsule Endoscopy in Patients With Chronic Abdominal Pain


Increased Diagnostic Yield of Capsule Endoscopy in Patients With Chronic Abdominal Pain

Liping Yang et al. PLoS One.


Background and study aims: Chronic abdominal pain is one of the most common chief complaints, but the underlying pathophysiology often remains unknown after routine clinical evaluation. Capsule endoscopy (CE) is a new technique for the visualization of the entire small bowel. The aim of this study was to evaluate the diagnostic efficacy of CE in patients with chronic abdominal pain of obscure origin.

Patients and methods: Two hundred forty three patients with chronic abdominal pain with no significant lesions were enrolled in this study. CE was performed in all patients.

Results: A diagnosis was made in 23.0% of patients screened with CE. Of the 243 patients, 19 (7.8%) were diagnosed with Crohn's disease, 15 (6.2%) with enteritis, 11 (4.5%) with idiopathic intestinal lymphangiectasia, 5 (2.1%) with uncinariasis, and a number of other diagnoses including small bowel tumor, ascariasis, and anaphylactoid purpura. Five patients had abnormal transit time, and capsule retention occurred in two patients.

Conclusions: In contrast to other previous studies, we found that CE is an effective diagnostic tool for patients with abdominal pain.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.


Figure 1
Figure 1. Ulcers and stenosis found by CE.
Ulcers and stenosis in the upper part of the small intestine were found by CE in a 56-year-old woman with abdominal pain. The diagnosis of Crohn's disease was confirmed both surgically and pathologically.
Figure 2
Figure 2. Hookworms identified by CE.
Hookworms throughout the small bowel were identified by CE in a 42-year-old woman with lower abdominal pain for three years.
Figure 3
Figure 3. Roundworm detected by CE.
Roundworm was detected by CE in the small bowel in a 49-year-old woman with periumbilial pain for more than one year.
Figure 4
Figure 4. An occupying lesion identified by CE.
An occupying lesion was identified by CE in the jejunum of a 52-year-old woman with abdominal pain for more than three months. With subsequent pathology evaluation, a diagnosis of adenocarcinoma was confirmed.
Figure 5
Figure 5. An eminence lesion identified by CE.
An eminence lesion was identified by CE in the small bowel of a 30-year-old man with periumbilial pain. The lesion was surgically diagnosed as gastrointestinal stromal tumor.
Figure 6
Figure 6. Multiple congestion and ulcers identified by CE.
Multiple congestion and ulcers in the small bowel were identified by CE in a 17-year-old man with recurrent abdominal pain.

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The authors have no support or funding to report.