The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration

Oncoimmunology. 2013 Dec 1;2(12):e26788. doi: 10.4161/onci.26788. Epub 2013 Oct 22.


A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8+ T cells located in the proximity of malignant lesions are associated with a survival advantage, suggesting the existence of immunoediting. Pancreatic stellate cells appear to dictate the infiltration of the juxtatumoral stroma by CD8+ T cells.

Keywords: B cells; CD8+ T cells; macrophages; natural killer cells; neutrophils.