Efficacy of vitamin E to prevent dermal complications of isotretinoin

Pak J Biol Sci. 2013 Jun 1;16(11):548-50. doi: 10.3923/pjbs.2013.548.550.


Acne treatment depends on whether patents have a mild, moderate, or severe type of acne. The aim of this study was to compare the using of Isotretinoin (Rokutan) with and without oral vitamin E in treating acne. This study was performed on 60 patients on 0.5 mg/kg/day isotretinoin treatment for 6 months. The first group received 800 IU day(-1) Vit E during treatment and the second group recieved 800 Iu day(-1) cod liver oil capsules. All patients were observed for the complications at 1th, 4th and 6th weeks during treatment. Cheilitis was the most common side effect among these patients (69%). Epistaxis was the second side effect in both groups (22%). Other side effects were xerosis, pruritus, epigastric pain and nail fragility. The frequency and the severity of complications were less common at 4th and 6th weeks of treatment. Isotretinoin is a useful and effective drug in treating severe and treatment-resistance acne lesions.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / diagnosis
  • Acne Vulgaris / drug therapy*
  • Administration, Oral
  • Adolescent
  • Adult
  • Capsules
  • Cheilitis / etiology
  • Cheilitis / prevention & control
  • Chi-Square Distribution
  • Cod Liver Oil / administration & dosage
  • Dermatologic Agents / adverse effects*
  • Epistaxis / etiology
  • Epistaxis / prevention & control
  • Female
  • Humans
  • Isotretinoin / adverse effects*
  • Male
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome
  • Vitamin E / administration & dosage*
  • Young Adult


  • Capsules
  • Dermatologic Agents
  • Vitamin E
  • Cod Liver Oil
  • Isotretinoin