6'-O-Caffeoylarbutin inhibits melanogenesis in zebrafish

Nat Prod Res. 2014;28(12):932-4. doi: 10.1080/14786419.2014.883395. Epub 2014 Feb 5.

Abstract

6'-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6'-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6'-O-caffeoylarbutin. The result suggested that 6'-O-caffeoylarbutin could be a candidate natural product to serve as a skin-whitening ingredient with the merits of potent melanin inhibition, less toxicity and reversible melanin synthesis after stopping use.

Keywords: 6′-O-caffeoylarbutin; Vaccinium dunalianum; anti-melanogenic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arbutin / analogs & derivatives
  • Arbutin / chemistry
  • Arbutin / isolation & purification*
  • Arbutin / pharmacology*
  • Caffeic Acids / chemistry
  • Caffeic Acids / isolation & purification*
  • Caffeic Acids / pharmacology*
  • Dose-Response Relationship, Drug
  • Hydroquinones / chemistry
  • Melanins / antagonists & inhibitors*
  • Melanins / metabolism
  • Skin / drug effects
  • Zebrafish / metabolism*

Substances

  • 6'-O-caffeoylarbutin
  • Caffeic Acids
  • Hydroquinones
  • Melanins
  • Arbutin
  • hydroquinone