Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 6 (1), 294

Seroepidemiology of Toxoplasma Gondii Infection in Drivers Involved in Road Traffic Accidents in the Metropolitan Area of Guadalajara, Jalisco, Mexico


Seroepidemiology of Toxoplasma Gondii Infection in Drivers Involved in Road Traffic Accidents in the Metropolitan Area of Guadalajara, Jalisco, Mexico

Ma de la Luz Galván-Ramírez et al. Parasit Vectors.


Background: The prevalence of toxoplasmosis in the general population of Guadalajara, Mexico, is around 32%. Toxoplasmosis can cause ocular lesions and slowing of reaction reflexes. Latent toxoplasmosis has been related with traffic accidents. We aimed to assess the prevalence of anti-Toxoplasma gondii antibodies and visual impairments related with traffic accidents in drivers from the metropolitan Guadalajara.

Methods: We prospectively evaluated the prevalence of IgG and IgM anti-T. gondii antibodies in 159 individuals involved in traffic accidents, and in 164 control drivers never involved in accidents. Cases of toxoplasmosis reactivation or acute infection were detected by PCR in a subset of 71 drivers studied for the presence of T. gondii DNA in blood samples. Ophthalmologic examinations were performed in drivers with IgG anti-T. gondii antibodies in search of ocular toxoplasmosis.

Results: Fifty-four (34%) traffic accident drivers and 59 (36%) controls were positive to IgG anti-T. gondii antibodies (p = 0.70). Among the 113 seropositive participants, mean anti-T. gondii IgG antibodies titers were higher in traffic accident drivers than in controls (237.9 ± 308.5 IU/ml vs. 122.9 ± 112.7 IU/ml, respectively; p = 0.01 by Student's t test, p = 0.037 by Mann-Whitney U test). In multivariate analyses, anti-T. gondii IgG antibody titers were consistently associated with an increased risk of traffic accidents, whereas age showed an inverse association. The presence of IgM-anti-T. gondii antibodies was found in three (1.9%) subjects among traffic accident drives, and in two (1.2%) controls. Three (4.2%) samples were positive for the presence of T. gondii DNA, all among seropositive individuals. No signs of ocular toxoplasmosis were found in the entire cohort. Moreover, no other ocular conditions were found to be associated with the risk of traffic accidents in a multivariate analysis.

Conclusions: Anti-T. gondii antibody titers are associated with the risk of traffic accidents. We could not determine any association of ocular toxoplasmosis with traffic accidents. Our results warrant further analyses in order to clarify the link between toxoplasmosis and traffic accidents.


Figure 1
Figure 1
Frequency of anti-T. gondii IgG antibodies in serum of the participants, according to age. a: the total cohort. b: control drivers, c: traffic accident drivers.
Figure 2
Figure 2
Anti-T. gondii IgG antibodies titers. a: antibody titers according to study group. b: correlation of antibody titers with age among control drivers. c: correlation of antibody titers with age among traffic accident drivers.

Similar articles

See all similar articles

Cited by 5 articles


    1. Galván-Ramírez ML, Mondragón-Flores R. Toxoplasmosis humana. Guadalajara Jalisco Mexico: Editorial Cuellar; 2001.
    1. Galván-Ramírez ML, Covarrubias X, Rodríguez R, Troyo R, Alfaro N, Correa D. Toxoplasma gondii antibodies in Mexican blood donors. Transfusion. 2005;45:281–282. - PubMed
    1. Yolken RH, Torrey EF. Are some cases of psychosis caused by microbial agents? a review of the evidence. Mol Psychiatry. 2008;13:470–479. doi: 10.1038/mp.2008.5. - DOI - PubMed
    1. Galván-Ramírez ML, Troyo R, Roman S, Calvillo-Sanchez C, Bernal-Redondo R. A systematic review and meta-analysis of toxoplasma gondii infection among the Mexican population. Parasit Vectors. 2012;5:271. doi: 10.1186/1756-3305-5-271. - DOI - PMC - PubMed
    1. Flegr J, Zitková S, Kodym P, Frynta D. Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology. 1996;113:49–54. doi: 10.1017/S0031182000066269. - DOI - PubMed

Publication types

MeSH terms