KIR/HLA immunogenetic background influences the evolution of hepatocellular carcinoma

Elisabetta Cariani; Gabriele Missale

doi:10.4161/onci.26622

KIR/HLA immunogenetic background influences the evolution of hepatocellular carcinoma

Oncoimmunology. 2013 Dec 1;2(12):e26622. doi: 10.4161/onci.26622. Epub 2013 Oct 21.

Authors

Elisabetta Cariani¹, Gabriele Missale²

Affiliations

¹ Clinical Pathology-Toxicology; Ospedale S Agostino-Estense; Modena, Italy.
² U.O. Infectious Diseases and Hepatology; Azienda Ospedaliero-Universitaria di Parma; Parma, Italy.

Abstract

Natural killer (NK) cells play a major role in antitumor immune responses. Recent results from our laboratory demonstrate the impact of the immunogenetic background on the activity of NK cells and hence on the outcome of hepatocellular carcinoma, disclosing perspectives for the development of NK-cell based therapies.

Keywords: CD56; HCC; HLA; immunotherapy; killer cell Ig-like receptor; natural killer cell.