[Assessment of concentrations of creatinine, uric acid and urea in non-smoking and smoking patients with chronic pancreatitis]

Przegl Lek. 2013;70(10):809-12.
[Article in Polish]

Abstract

Cigarette smoking is a major factor for pancreatic dysfunction in patients with chronic pancreatitis (CP). In the course of acute pancreatitis may lead to organ damage resulting in their failure. The chronic renal failure can cause disturbances in the exocrine pancreas. The study population consisted of 51 patients with chronic pancreatitis and 29 healthy subjects classified as the control group. The study population was divided into smokers and non-smokers on the basis of determining the concentration of cotinine (ELISA). It has been shown that the concentration of creatinine in the groups was in the range of reference values, but in non-smoking and smoking control group that is higher in comparison with patients (respectively 0.97 +/- 0.17 and 0.79 +/- 0.14 [mg/dl] , p = 0.0004; 1.00 +/- 0.14 and 0.78 +/- 0.23 [mg/dl], p = 0.0416). It has been shown 1.5 times higher uric acid concentration in the serum of smoking patients with chronic pancreatitis (245.67 +/- 79.73 micromol/l) compared to non-smoking control group (173.67 +/- 50.08 [micromol/l]). There was a significant difference between the mean value of urea nitrogen (BUN) in terms of the concentration of creatinine (index of BUN/creatinine) in the group of non-smoking healthy persons (13.38 +/- 4.53) and the average index of BUN/creatinine ratio in a group of nonsmoking and smoking patients with pancreatitis (respectively, 2.73 +/- 0.56, p < 0.0001 and 2.40 +/- 0.77, p < 0.0001). The results show that cigarette smoking may be an important factor in potential changes in uric acid levels in patients with chronic pancreatitis. In addition, reduced protein catabolism is the result of progressing exocrine pancreatic dysfunction in both smoking and non-smoking patients with chronic pancreatitis.

Publication types

  • English Abstract

MeSH terms

  • Creatinine / blood*
  • Disease Progression
  • Humans
  • Pancreatitis, Chronic / blood*
  • Pancreatitis, Chronic / complications*
  • Smoking / adverse effects*
  • Smoking / blood*
  • Urea / metabolism*
  • Uric Acid / blood*

Substances

  • Uric Acid
  • Urea
  • Creatinine