Effectiveness of acupuncture in treatment of patients with gastroesophageal reflux disease is investigated. Favourable effect on functional state of esophagus, neurohumoral regulation of lower esophageal sphincter, decrease of acid producing function of stomach is proven. Results obtained establish a ground to advise to a patients with non-erosive gastroesophageal reflux disease a treatment course of acupuncture on corporeal points as monotherapy combined with a diet.