Diagnostic accuracy of three biopsy techniques in 117 dogs with intra-nasal neoplasia

J Small Anim Pract. 2014 Apr;55(4):219-24. doi: 10.1111/jsap.12187. Epub 2014 Feb 7.


Objectives: To determine if nasal biopsies taken at rhinoscopy are more accurate for diagnosing neoplasia than biopsies taken blindly or using advanced imaging for guidance.

Methods: A retrospective study of 117 dogs with nasal mass lesions that were divided into three groups according to the method of nasal biopsy collection; advanced imaging-guided, rhinoscopy-guided and blind biopsy. Signalment, imaging and rhinoscopic findings, and histopathological diagnosis were compared between groups. The proportion of first attempt biopsies confirming neoplasia were determined for each group.

Results: There were no statistically significant differences in the proportion of biopsies that confirmed neoplasia obtained via advanced imaging-guided, rhinoscopy-guided or blind biopsy techniques.

Clinical significance: In dogs with a high index of suspicion of nasal neoplasia, blind biopsy may be as diagnostic as rhinoscopy-guided biopsy. Repeated biopsies are frequently required for definitive diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biopsy / methods
  • Biopsy / veterinary*
  • Dog Diseases / diagnosis*
  • Dog Diseases / pathology
  • Dogs
  • Endoscopy / methods
  • Endoscopy / veterinary
  • Nose / pathology
  • Nose Neoplasms / diagnosis
  • Nose Neoplasms / pathology
  • Nose Neoplasms / veterinary*
  • Retrospective Studies