Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection

Curr Pharm Des. 2014;20(36):5681-9. doi: 10.2174/1381612820666140204111236.


Caveolae are flask-like invaginations of the cell surface that have been identified as signaling epicenters. Within these microdomains, caveolins are structural proteins of caveolae, which are able to interact with numerous signaling molecules affecting temporal and spatial dimensions required in cardiac protection. This complex moiety is essential to the mechanisms involved in volatile anesthetics. In this review we will outline a general overview of caveolae and caveolins and their role in protective signaling with a focus on the effects of volatile anesthetics. These recent developments have allowed us to better understand the mechanistic effect of volatile anesthetics and their potential in cardiac protection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Anesthetics, Inhalation / pharmacology*
  • Animals
  • Caveolae / metabolism*
  • Caveolins / metabolism
  • Heart Diseases / physiopathology
  • Heart Diseases / prevention & control*
  • Humans
  • Signal Transduction / drug effects
  • Signal Transduction / physiology


  • Anesthetics, Inhalation
  • Caveolins