Evolving blood pressure dynamics for extremely preterm infants

J Perinatol. 2014 Apr;34(4):301-5. doi: 10.1038/jp.2014.6. Epub 2014 Feb 6.


Objective: To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants.

Study design: Prospective observational study of infants 23(0/7) to 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 h.

Result: A cohort of 367 infants had 18 709 ABP measurements recorded. ABP decreased for the first 3 h, reached a nadir at 4 to 5 h and then increased at an average rate of 0.2 mm Hg h(-1). The rise in ABP from hour 4 to 24 was similar for untreated infants (n=164) and infants given any antihypotensive therapy (n=203), a fluid bolus (n=135) or dopamine (n=92). GA-specific trends were similar. ABP tended to be lower as GA decreased, but varied widely at each GA.

Conclusion: ABP increased spontaneously over the first 24 postnatal hours for extremely preterm infants. The rate of rise in ABP did not change with antihypotensive therapy.

Publication types

  • Observational Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Arterial Pressure / drug effects
  • Arterial Pressure / physiology*
  • Female
  • Humans
  • Hypotension / drug therapy
  • Infant, Extremely Premature / physiology*
  • Infant, Newborn
  • Male
  • Prospective Studies