Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression

Med Princ Pract. 2014;23(3):239-45. doi: 10.1159/000358221. Epub 2014 Jan 31.


Objective: This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability.

Materials and methods: Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores.

Results: ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels.

Conclusion: Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation.

MeSH terms

  • Adult
  • Biomarkers
  • Cytokines / immunology
  • DNA-Binding Proteins / immunology*
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Guanine Nucleotide Exchange Factors / immunology*
  • Humans
  • Immunoglobulin G / immunology
  • Male
  • Middle Aged
  • Minor Histocompatibility Antigens
  • Multiple Sclerosis, Relapsing-Remitting / immunology*
  • Nuclear Proteins / immunology*


  • Biomarkers
  • Cytokines
  • DNA-Binding Proteins
  • Guanine Nucleotide Exchange Factors
  • Immunoglobulin G
  • Minor Histocompatibility Antigens
  • Nuclear Proteins
  • SWAP70 protein, human