Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein

Am J Pathol. 1988 Mar;130(3):443-54.


In this study the authors have developed a model with which can be studied directly the influence of circulating anti-myelin antibody on the clinical and pathologic course of inflammatory T-cell-mediated experimental allergic encephalomyelitis (EAE) in the rat. EAE was induced by passive transfer of either myelin basic protein (MBP)-activated spleen cells derived from sensitized donors or long-term-cultured MBP-specific T-cell lines. At the onset of the disease, monoclonal antibodies against a myelin/oligodendrocyte glycoprotein (MOG) were injected intravenously. This antigen is exposed on the surface of central nervous system myelin and oligodendrocytes. Intravenous injection of the antibody in the course of T-cell-mediated transfer EAE augmented the severity and duration of clinical signs and resulted in the formation of large, confluent demyelinated plaques.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal* / adverse effects
  • Demyelinating Diseases / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / complications*
  • Enzyme-Linked Immunosorbent Assay
  • Half-Life
  • Immunohistochemistry
  • Mice
  • Microscopy, Electron
  • Myelin Proteins / immunology*
  • Myelin-Associated Glycoprotein
  • Rats
  • Rats, Inbred Lew


  • Antibodies, Monoclonal
  • Myelin Proteins
  • Myelin-Associated Glycoprotein