Controlled study of verapamil for treatment of panic disorder

Am J Psychiatry. 1988 Apr;145(4):431-4. doi: 10.1176/ajp.145.4.431.


The authors conducted a 16-week double-blind, crossover study in 11 patients with panic disorder to study the effects of verapamil, a calcium channel blocker commonly used in the treatment of cardiovascular disorders, on the treatment of panic disorder. Their findings suggest that verapamil has modest antianxiety and antipanic properties.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Clinical Trials as Topic
  • Double-Blind Method
  • Fear* / drug effects
  • Female
  • Humans
  • Ion Channels / drug effects
  • Male
  • Middle Aged
  • Panic* / drug effects
  • Personality Inventory
  • Psychiatric Status Rating Scales
  • Verapamil / pharmacology
  • Verapamil / therapeutic use*


  • Ion Channels
  • Verapamil