The Possible Association of Hidradenitis Suppurativa and Down Syndrome: Is Increased Amyloid Precursor Protein Expression Resulting in Impaired Notch Signalling the Missing Link?

Br J Dermatol. 2014 Jun;170(6):1375-7. doi: 10.1111/bjd.12887.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adolescent
  • Amyloid beta-Protein Precursor / metabolism*
  • Down Syndrome / complications*
  • Down Syndrome / genetics
  • Down Syndrome / metabolism
  • Female
  • Genetic Predisposition to Disease / genetics
  • Hidradenitis Suppurativa / complications*
  • Hidradenitis Suppurativa / genetics
  • Hidradenitis Suppurativa / metabolism
  • Humans
  • Male
  • Receptors, Notch / metabolism*
  • Signal Transduction
  • Young Adult

Substances

  • Amyloid beta-Protein Precursor
  • Receptors, Notch