[Lipid peroxidation and the response of the antioxidant defense system in the obese type 2 diabetic compared with the non-obese type 2 diabetic]

Nutr Hosp. 2013 Nov 1;28(6):1905-11.
[Article in Spanish]

Abstract
in English, Spanish

Introduction: Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage.

Objective: To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals.

Methods: Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).

Results: Two groups of 30 subjects were studied. The obese DM2 group had a mean body mass index (BMI) 38.6 ± 3.5 kg m(-2) compared to the control group 24.7 ± 3.6 kg m(-2) (p<0.01). TBARS levels in the study group were higher compared to the control group (p <0.01). Multiple linear regression analysis suggested that activities of SOD and CAT adjusted to lipid peroxidation (TBARS) in the obese DM2 individuals.

Conclusion: TBARS levels suggest greater oxidative damage in obese DM2 subjects with a diminished response of ADS.

Introducción: La diabetes se asocia a un incremento en la peroxidación de lípidos, cuantificada a partir del nivel de sustancias reactivas al ácido tiobarbitúrico (TBARS). En paralelo, se activa el sistema de defensa antioxidante (SDA) para delimitar el daño. Objetivo: Determinar el grado de peroxidación de lípidos en individuos obesos diabéticos tipo 2 (DM2) y la respuesta del SDA en comparación con individuos con DM2 sin obesidad. Método: Se evaluó el daño a lípidos a través de la medición de las TBARS en dos grupos de 30 individuos. Se evaluó la respuesta del SDA por medio de la medición de la actividad de las enzimas catalasa (CAT), superóxido dismutasa (SOD) y glutatión peroxidasa (GPx). Resultados: El grupo de DM2 obesos presentó un índice de masa corporal (IMC) promedio de 38.6 ± 3.5 kg m-2 en comparación con el grupo control 24.7 ± 3.6 kg m-2 (p.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Antioxidants / metabolism*
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / metabolism*
  • Female
  • Humans
  • Lipid Peroxidation*
  • Male
  • Obesity / metabolism*
  • Thiobarbituric Acid Reactive Substances / analysis
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Antioxidants
  • Thiobarbituric Acid Reactive Substances