High-density lipoproteins put out the fire

Cell Metab. 2014 Feb 4;19(2):175-6. doi: 10.1016/j.cmet.2014.01.009.

Abstract

Macrophages in atherosclerotic plaques are activated, inflammatory cells that directly contribute to the disease process. De Nardo et al. (2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.

Publication types

  • Comment

MeSH terms

  • Activating Transcription Factor 3 / metabolism*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Atherosclerosis / therapy*
  • Cholesterol / metabolism*
  • Female
  • Humans
  • Inflammation / therapy*
  • Lipoproteins, HDL / therapeutic use*
  • Macrophages / drug effects*

Substances

  • Activating Transcription Factor 3
  • Anti-Inflammatory Agents, Non-Steroidal
  • Lipoproteins, HDL
  • Cholesterol