NAD+ deficiency in age-related mitochondrial dysfunction

Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.


Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.

Publication types

  • Comment

MeSH terms

  • Aging / pathology*
  • Animals
  • Cell Nucleus / metabolism*
  • Mitochondria / metabolism*
  • NAD / metabolism*
  • Oxidative Phosphorylation*


  • NAD