Role of infections

Clin Chest Med. 2014 Mar;35(1):87-100. doi: 10.1016/j.ccm.2013.09.012.


This article represents a review of the current literature on the role of infection in the pathogenesis of chronic obstructive pulmonary disease (COPD), in stable disease, exacerbations, and pneumonia. It outlines the complex interactions between respiratory pathogens and host immune defenses that underlie the clinical manifestations of infection in COPD.

Keywords: Airway colonization; Chronic infection; Infection in COPD; Innate immunity in COPD; New strain exacerbations; Pneumonia and COPD; Vicious-circle hypothesis; Virulence factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacterial Infections / complications
  • Chronic Disease
  • Humans
  • Pulmonary Disease, Chronic Obstructive / complications*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Respiratory Tract Infections / complications*
  • Respiratory Tract Infections / physiopathology
  • Virus Diseases / complications