New roles for the BLyS/BAFF family in antigen-experienced B cell niches

Cytokine Growth Factor Rev. 2014 Apr;25(2):107-13. doi: 10.1016/j.cytogfr.2014.01.001. Epub 2014 Jan 10.


BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.

Keywords: BAFF; BLyS; Germinal center; TACI.

Publication types

  • Review

MeSH terms

  • Antigen Presentation / immunology*
  • B-Cell Activating Factor / immunology*
  • B-Lymphocytes / immunology*
  • Cell Differentiation / immunology
  • Cell Survival / immunology
  • Germinal Center / immunology
  • Humans
  • Tumor Necrosis Factor Ligand Superfamily Member 13 / immunology


  • B-Cell Activating Factor
  • TNFSF13B protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 13