Systemic necrotizing vasculitis induced by isoniazid

Cardiovasc Pathol. May-Jun 2014;23(3):181-2. doi: 10.1016/j.carpath.2014.01.002. Epub 2014 Jan 11.

¹ Department of Anatomic Pathology, The Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA. Electronic address: tanc@ccf.org.
² Department of Anatomic Pathology, The Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA.

Abstract

A rare fatal case of antineutrophil cytoplasmic antibody-positive vasculitis induced by isoniazid is described.

Keywords: ANCA; Isoniazid; Vasculitis.

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / chemically induced*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy
Antitubercular Agents / adverse effects*
Arteries / drug effects*
Arteries / pathology
Autopsy
Disease Progression
Fatal Outcome
Humans
Immunosuppressive Agents / therapeutic use
Isoniazid / adverse effects*
Latent Tuberculosis / drug therapy*
Male
Middle Aged
Necrosis
Treatment Failure