Peroxisomes: a nexus for lipid metabolism and cellular signaling

Cell Metab. 2014 Mar 4;19(3):380-92. doi: 10.1016/j.cmet.2014.01.002. Epub 2014 Feb 6.


Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adipocytes / metabolism
  • Fatty Acids / chemistry
  • Fatty Acids / metabolism
  • Humans
  • Lipid Metabolism / physiology*
  • Mitochondria / metabolism
  • PPAR gamma / metabolism
  • Peroxisomal Disorders / metabolism
  • Peroxisomal Disorders / pathology
  • Peroxisomes / metabolism*
  • Phospholipid Ethers / metabolism
  • Signal Transduction


  • Fatty Acids
  • PPAR gamma
  • Phospholipid Ethers