Progress toward an efficient panel of SNPs for ancestry inference

Forensic Sci Int Genet. 2014 May;10:23-32. doi: 10.1016/j.fsigen.2014.01.002. Epub 2014 Jan 15.

Abstract

Many panels of ancestry informative single nucleotide polymorphisms have been proposed in recent years for various purposes including detecting stratification in biomedical studies and determining an individual's ancestry in a forensic context. All of the panels have limitations in their generality and efficiency for routine forensic work. Some panels have used only a few populations to validate them. Some panels are based on very large numbers of SNPs thereby limiting the ability of others to test different populations. We have been working toward an efficient and globally useful panel of ancestry informative markers that is comprised of a small number of highly informative SNPs. We have developed a panel of 55 SNPs analyzed on 73 populations from around the world. We present the details of the panel and discuss its strengths and limitations.

Keywords: AIM; Ancestry; Population differentiation; SNP; Structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Forensic Genetics
  • Humans
  • Pedigree*
  • Polymorphism, Single Nucleotide*