Abstract
We report here an unusual case of delayed hypersensitivity reaction in a young woman with ulcerative colitis after the first administration of infliximab (IFX). The patient developed severe serum-sickness-like reaction, and her anti-IFX antibody titer increased rapidly after a single infusion of IFX. The possible reason for the delayed hypersensitivity reaction to a single IFX exposure might be the presensitization of the patient by murine antigens as she had been keeping mice and hamsters as pets for several years.
MeSH terms
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Animals
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Anti-Inflammatory Agents / adverse effects*
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Anti-Inflammatory Agents / immunology
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Antibodies / blood
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal / immunology
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Colitis, Ulcerative / drug therapy*
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Cricetinae / immunology
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Drug Hypersensitivity / blood
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Drug Hypersensitivity / diagnosis
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Drug Hypersensitivity / etiology*
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Drug Hypersensitivity / immunology
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Drug Substitution
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Female
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Gastrointestinal Agents / adverse effects*
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Gastrointestinal Agents / immunology
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Humans
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Hypersensitivity, Delayed / blood
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Hypersensitivity, Delayed / chemically induced*
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Hypersensitivity, Delayed / diagnosis
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Hypersensitivity, Delayed / immunology
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Infliximab
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Mice / immunology
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Pets / immunology
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Risk Factors
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Young Adult
Substances
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Anti-Inflammatory Agents
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Antibodies
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Antibodies, Monoclonal
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Gastrointestinal Agents
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Infliximab