Computational large-scale mapping of protein-protein interactions using structural complexes

Curr Protoc Protein Sci. 2013 Sep 24:73:3.9.1-3.9.9. doi: 10.1002/0471140864.ps0309s73.


Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.

Keywords: IBIS; Inferred Biomolecular Interactions Server; binding interface; protein interaction; structural complex.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Computational Biology / methods*
  • Internet*
  • Models, Molecular
  • Protein Interaction Mapping / methods*
  • Proteins* / chemistry
  • Proteins* / metabolism
  • Software*


  • Proteins