Computational large-scale mapping of protein-protein interactions using structural complexes

Abstract

Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.

Keywords: IBIS; Inferred Biomolecular Interactions Server; binding interface; protein interaction; structural complex.