An Integrated Microrobotic Platform for On-Demand, Targeted Therapeutic Interventions

Adv Mater. 2014 Feb 12;26(6):952-7. doi: 10.1002/adma.201304098. Epub 2013 Nov 4.

Abstract

The presented microrobotic platform combines together the advantages of self-folding NIR light sensitive polymer bilayers, magnetic alginate microbeads, and a 3D manipulation system, to propose a solution for targeted, on-demand drug and cell delivery. First feasibility studies are presented together with the potential of the full design.

Keywords: alginate microbeads; microrobotics; responsive hydrogels; self-folding; targeted drug and cell delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates
  • Animals
  • Cell Culture Techniques
  • Cell Proliferation
  • Cell Survival
  • Drug Delivery Systems / instrumentation*
  • Equipment Design
  • Feasibility Studies
  • Glucuronic Acid
  • Graphite
  • Hexuronic Acids
  • Hydrogels
  • Lasers
  • Magnetic Fields
  • Magnetite Nanoparticles
  • Mesenchymal Stem Cells / physiology
  • Mice
  • Microspheres
  • Microtechnology / instrumentation*
  • Nanocomposites
  • Robotics / instrumentation*
  • Temperature

Substances

  • Alginates
  • Hexuronic Acids
  • Hydrogels
  • Magnetite Nanoparticles
  • Graphite
  • Glucuronic Acid