Vaccination models and optimal control strategies to dengue

Math Biosci. 2014 Jan:247:1-12. doi: 10.1016/j.mbs.2013.10.006.


As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of efficacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aedes / virology
  • Animals
  • Basic Reproduction Number
  • Child
  • Computer Simulation
  • Dengue / immunology*
  • Dengue / prevention & control
  • Dengue / virology
  • Dengue Vaccines / administration & dosage
  • Dengue Vaccines / immunology*
  • Dengue Virus / immunology*
  • Disease Outbreaks / prevention & control*
  • Humans
  • Models, Immunological*
  • Vaccination / standards*


  • Dengue Vaccines