Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

Cancer Lett. 2014 Mar 1;344(1):13-19. doi: 10.1016/j.canlet.2013.10.015.

Abstract

Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg–/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg(–/–) mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Humans
  • Interleukin Receptor Common gamma Subunit / deficiency
  • Interleukin Receptor Common gamma Subunit / genetics
  • Mice
  • Mice, Inbred NOD
  • Mice, Knockout
  • Mice, SCID
  • Mice, Transgenic
  • Neoplasms*
  • Precision Medicine / methods*
  • Precision Medicine / trends
  • Xenograft Model Antitumor Assays / methods*

Substances

  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit