Detection of Leishmania donovani soluble antigen and antibody in the urine of visceral leishmaniasis patients

Trans R Soc Trop Med Hyg. 1987;81(4):578-80. doi: 10.1016/0035-9203(87)90414-7.

Abstract

Urine samples from 21 patients with visceral leishmaniasis were examined for the presence of Leishmania donovani soluble antigen and antibody by double counter-current immunoelectrophoresis. 19 samples revealed both antigen and antibody (IgM in 5 and IgG in all samples). 2 urine samples collected 10 and 13 days after Glucantime treatment revealed only antibody (IgG), not soluble antigen.

MeSH terms

  • Animals
  • Antibodies, Protozoan / urine*
  • Antigens, Protozoan / urine*
  • Child
  • Counterimmunoelectrophoresis
  • Epitopes
  • Humans
  • Immunodiffusion
  • Immunoglobulin G / urine
  • Leishmania donovani / immunology*
  • Leishmaniasis, Visceral / immunology*
  • Leishmaniasis, Visceral / urine

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Epitopes
  • Immunoglobulin G