Structure and function of toll-like receptor 8

Umeharu Ohto; Hiromi Tanji; Toshiyuki Shimizu

doi:10.1016/j.micinf.2014.01.007

Structure and function of toll-like receptor 8

Microbes Infect. 2014 Apr;16(4):273-82. doi: 10.1016/j.micinf.2014.01.007. Epub 2014 Feb 8.

Authors

Umeharu Ohto¹, Hiromi Tanji¹, Toshiyuki Shimizu²

Affiliations

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
² Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; CREST, JST, Japan. Electronic address: shimizu@mol.f.u-tokyo.ac.jp.

PMID: 24513445
DOI: 10.1016/j.micinf.2014.01.007

Abstract

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms.

Keywords: Innate immunity; Structural biology; Toll-like receptor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Models, Molecular
Protein Binding
Receptors, Immunologic / chemistry*
Receptors, Immunologic / metabolism*
Signal Transduction
Toll-Like Receptor 8 / chemistry*
Toll-Like Receptor 8 / metabolism*

Substances

Receptors, Immunologic
Toll-Like Receptor 8