Insulin-like growth factor binding protein-related protein 1 and cancer

Clin Chim Acta. 2014 Apr 20:431:23-32. doi: 10.1016/j.cca.2014.01.037. Epub 2014 Feb 7.

Abstract

Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) belongs to the IGFBP family whose members have a conserved structural homology. It has a low affinity for IGFs and a high affinity for insulin, suggesting that IGFBP-rP1 may have a biological function distinct from other members of the family. IGFBP-rP1 is ubiquitously expressed in normal human tissues and has diverse biological functions, regulating cell proliferation, apoptosis and senescence; it may also have a key role in vascular biology. Increasing evidence suggests that IGFBP-rP1 acts as a tumor suppressor. It elicits its biological effects by both insulin/IGF-dependent and -independent mechanisms. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer, as well as the underlying molecular mechanisms.

Keywords: Cancer; IGF; IGFBP-rP1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fibrosis / pathology
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1 / biosynthesis
  • Insulin-Like Growth Factor Binding Protein 1 / chemistry
  • Insulin-Like Growth Factor Binding Protein 1 / genetics
  • Insulin-Like Growth Factor Binding Protein 1 / physiology*
  • Neoplasms / metabolism*
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Physiologic / physiology

Substances

  • Insulin-Like Growth Factor Binding Protein 1