Stressing on the nucleolus in cardiovascular disease

Biochim Biophys Acta. 2014 Jun;1842(6):798-801. doi: 10.1016/j.bbadis.2013.09.016. Epub 2013 Oct 24.


The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

Keywords: Cardiovascular; Disease; Heart; Nucleolus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cell Nucleolus / genetics
  • Cell Nucleolus / metabolism*
  • Cell Proliferation
  • Fibrillins
  • Humans
  • Microfilament Proteins / metabolism
  • Nuclear Proteins / metabolism*
  • Nucleophosmin
  • Phosphoproteins / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Signal Transduction


  • Fibrillins
  • Microfilament Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • RNA-Binding Proteins
  • nucleolin
  • Nucleophosmin