Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca

Arch Ophthalmol. 1988 Apr;106(4):484-7. doi: 10.1001/archopht.1988.01060130530029.


An unpreserved artificial tear substitute containing 0.1% sodium hyaluronate was compared with a preparation containing 1.4% polyvinyl alcohol and 0.5% chlorobutanol in a controlled, double-masked, randomized study in patients with moderately severe keratoconjunctivitis sicca. Patients were evaluated initially, at 1, 4, and 8 weeks. The dry-eye status was evaluated by means of tear-film osmolality, tear breakup time, rose bengal staining, Schirmer's test (without anesthesia), and ocular surface-impression cytology. In general, neither preparation was found to be superior to the other. In both study groups, the mean tear-film osmolality and rose bengal staining score improved over the eight-week study, but the degree of squamous metaplasia of the bulbar conjunctival surface, as shown by impression cytology, did not change significantly.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Keratoconjunctivitis / drug therapy*
  • Keratoconjunctivitis Sicca / drug therapy*
  • Keratoconjunctivitis Sicca / pathology
  • Osmolar Concentration
  • Palliative Care
  • Polyvinyl Alcohol / therapeutic use*
  • Povidone / analogs & derivatives*
  • Povidone-Iodine / therapeutic use*
  • Rose Bengal
  • Staining and Labeling


  • Rose Bengal
  • Povidone-Iodine
  • Polyvinyl Alcohol
  • Hyaluronic Acid
  • Povidone