Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation

Int J Med Sci. 2014 Jan 21;11(3):268-75. doi: 10.7150/ijms.7769. eCollection 2014.


Background: Metastasis-associated in colon cancer-1 (MACC1) acts as a promoter of tumor metastasis; however, the predictive value of MACC1 for hepatocellular carcinoma (HCC) after liver transplantation (LT) remains unclear.

Methods: We examined the expression of MACC1 and its target genes MET and FAK by quantitative PCR in 160 patients with HCC that was undergone LT.

Results: The patients with MACC1(high) or FAK(high) in HCCs showed a significantly shorter overall survival and higher cumulative recurrence rates after liver transplantation (LT), compared with MACC1(low) or FAK(low) group. Multivariate analysis indicated that MACC1 alone or combination of MACC1/FAK was an independent prognostic factor for overall survival and cumulative recurrence.

Conclusions: MACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT.

Keywords: hepatocellular carcinoma; liver transplantation; metastasis; metastasis-associated in colon cancer-1; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / biosynthesis*
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology
  • Female
  • Focal Adhesion Kinase 1 / biosynthesis*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kaplan-Meier Estimate
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Liver Transplantation / adverse effects
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • Proto-Oncogene Proteins c-met / biosynthesis
  • Trans-Activators
  • Transcription Factors / biosynthesis*


  • Biomarkers, Tumor
  • MACC1 protein, human
  • Trans-Activators
  • Transcription Factors
  • MET protein, human
  • Proto-Oncogene Proteins c-met
  • Focal Adhesion Kinase 1
  • PTK2 protein, human