Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions

PLoS One. 2014 Feb 7;9(2):e88139. doi: 10.1371/journal.pone.0088139. eCollection 2014.


There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholera / prevention & control*
  • Cholera Vaccines / therapeutic use*
  • Health Promotion / methods*
  • Humans
  • Mass Vaccination*
  • Program Evaluation / methods*


  • Cholera Vaccines

Grant support

This work is included under the Delivering Oral Vaccine Effectively (DOVE) project funded by the Bill & Melinda Gates Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.