Clostridium difficile infection: a worldwide disease

Gut Liver. 2014 Jan;8(1):1-6. doi: 10.5009/gnl.2014.8.1.1. Epub 2014 Jan 13.


Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and diminished host immune response contribute to symptomatic disease. C. difficile has been a well-established pathogen in North America and Europe for decades, but is just emerging in Asia. This article reviews the epidemiology, microbiology, pathophysiology, and clinical management of C. difficile. Prompt recognition of C. difficile is necessary to implement appropriate infection control practices.

Keywords: Asia; Clostridium difficile; Epidemiology; Review.

Publication types

  • Review

MeSH terms

  • Asia / epidemiology
  • Clostridioides difficile / genetics
  • Clostridioides difficile / pathogenicity*
  • Clostridium Infections / diagnosis*
  • Clostridium Infections / epidemiology
  • Clostridium Infections / microbiology
  • Clostridium Infections / therapy*
  • Europe / epidemiology
  • Global Health
  • Humans
  • North America / epidemiology